THE BASIC PRINCIPLES OF LACHGAS

The last proposed mechanism of RBC vasodilation while in the existence of nitrite may be the reduction of nitrite to NO by Hb. Brooks very first studied the nitrite Hb interaction in 1937 and this get the job done was later extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to form metHb and NO (Brooks